SrasV1, France, Analysis, bibRecord, 000309

Two-Year Prospective Study of the Humoral Immune Response of Patients with Severe Acute Respiratory Syndrome

Identifieur interne : 000309 ( France/Analysis ); précédent : 000308; suivant : 000310

Two-Year Prospective Study of the Humoral Immune Response of Patients with Severe Acute Respiratory Syndrome

Auteurs : Wei Liu ; Arnaud Fontanet [France] ; Pan-He Zhang ; Lin Zhan ; Zhong-Tao Xin [République populaire de Chine] ; Laurence Baril [France] ; Fang Tang ; Hui Lv ; Wu-Chun Cao

Source :

The Journal of Infectious Diseases [ 0022-1899 ] ; 2006.

RBID : ISTEX:DE3BBF473504ED5098E72D64D5DEBF6212E3CC8E

Descripteurs français

KwdFr :
- Anticorps antiviraux (immunologie), Anticorps antiviraux (sang), Humains, Immunoglobuline G (sang), Production d'anticorps, Syndrome respiratoire aigu sévère (immunologie), Syndrome respiratoire aigu sévère (virologie), Tests de neutralisation, Virus du SRAS (immunologie), Études de cohortes, Études prospectives.
MESH :
- immunologie : Anticorps antiviraux, Syndrome respiratoire aigu sévère, Virus du SRAS.
- sang : Anticorps antiviraux, Immunoglobuline G.
- virologie : Syndrome respiratoire aigu sévère.
- Humains, Production d'anticorps, Tests de neutralisation, Études de cohortes, Études prospectives.

English descriptors

KwdEn :
- Antibodies, Viral (blood), Antibodies, Viral (immunology), Antibody Formation, Cohort Studies, Humans, Immunoglobulin G (blood), Neutralization Tests, Prospective Studies, SARS Virus (immunology), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (virology).
MESH :
- chemical , blood : Antibodies, Viral, Immunoglobulin G.
- chemical , immunology : Antibodies, Viral.
- immunology : SARS Virus, Severe Acute Respiratory Syndrome.
- virology : Severe Acute Respiratory Syndrome.
- Antibody Formation, Cohort Studies, Humans, Neutralization Tests, Prospective Studies.

Abstract

In a cohort study of 56 convalescent patients with severe acute respiratory syndrome (SARS), titers of immunoglobulin G (IgG) antibodies and neutralizing antibodies (NAbs) against SARS-associated coronavirus were assessed at regular intervals (at 1, 4, 7, 10, 16, and 24 months after the onset of disease) by use of enzyme-linked immunosorbent assay and neutralization assay. IgG antibody and NAb titers were highly correlated, peaking at month 4 after the onset of disease and decreasing thereafter. IgG antibodies remained detectable in all patients until month 16, and they became undetectable in 11.8% of patients at month 24. The finding that NAbs remained detectable throughout follow-up is reassuring in terms of protection provided against reinfection; however, NAb titers decreased markedly after month 16

Url:

DOI: 10.1086/500469

Affiliations:

Links to Exploration step

ISTEX:DE3BBF473504ED5098E72D64D5DEBF6212E3CC8E

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<front><div type="abstract">In a cohort study of 56 convalescent patients with severe acute respiratory syndrome (SARS), titers of immunoglobulin G (IgG) antibodies and neutralizing antibodies (NAbs) against SARS-associated coronavirus were assessed at regular intervals (at 1, 4, 7, 10, 16, and 24 months after the onset of disease) by use of enzyme-linked immunosorbent assay and neutralization assay. IgG antibody and NAb titers were highly correlated, peaking at month 4 after the onset of disease and decreasing thereafter. IgG antibodies remained detectable in all patients until month 16, and they became undetectable in 11.8% of patients at month 24. The finding that NAbs remained detectable throughout follow-up is reassuring in terms of protection provided against reinfection; however, NAb titers decreased markedly after month 16</div>
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Two-Year Prospective Study of the Humoral Immune Response of Patients with Severe Acute Respiratory Syndrome

Two-Year Prospective Study of the Humoral Immune Response of Patients with Severe Acute Respiratory Syndrome

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Descripteurs français

English descriptors

Abstract

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